The effect of high perfusion pressures on the granulation of juxtaglomerular cells in an isolated kidney.

In our previous studies on the granulation of juxtaglomerular cells, we were impressed with several experiments in which a kidney was perfused with blood at a high pressure and had a striking decrease in the juxtaglomerular granulation (1). Conversely, in other situations where the pressure of the blood perfusing the kidney was reduced, the juxtaglomerular granulation tended to increase (1). These relationships can easily be indirect or coincidental, and it seemed of interest to find out whether changes in perfusion pressure can directly alter the granulation of these cells.